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TEM2 Antibody

Catalog # Availability Size / Price Inquiry
APR06470G 0.1 mg / $695

TEM2 Antibody

Brand

Leading Biology

Catalog Number

APR06470G

Product Type

Polyclonal Antibodies

Field of Research

Product Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TEM2 Antibody.

Molecular Weight

30366 Da

Cellular Localization

Antigen Cellular Localization: Cell membrane; Lipid-anchor

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Target

RASD2; TEM2 antibody may cross-react with the closely related protein RASD1.

Isotype

IgG

Symbol

TEM2

GeneID

UniProt ID

Function

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.

Summary

TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.

Storage & Stability

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Applications

WB, IHC-P, IF, E

Images

Western blot analysis of TEM2 in rat colon tissue lysate with TEM2 antibody at (A) 1 and (B) 2 μg/mL.

Immunohistochemistry of TEM2 in human colon tissue with TEM2 antibody at 2.5 μg/mL.

Immunofluorescence of TEM2 in Human Colon cells with TEM2 antibody at 20 μg/mL.

Specification

Quantity

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