> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human FGF21 Protein(N-His Tag)Brand |
Leading Biology | Catalog Number |
PH0111E3 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Human
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AA Sequence |
NP_061986.1(His 29-Ser 209)
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Tags |
N-His
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Molecular Weight |
23KD
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Activity |
Measured in a cell proliferation assay using BaF3 mouse pro?B cells transfected with human FGF RIIIc.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered 50 mM Tris, 10 % glycerol, 0.05 % Brij 35, pH 8.0
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Product Description |
FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Treatment of animals with FGF21 results in increased energy expenditure, fat utilization and lipid excretion. Beta Klotho (KLB) functions as a cofactor essential for FGF21 activity.
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Synonyms |
UNQ3115 / PRO10196 Protein(Human)
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Images |
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Quantity |
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