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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human TIMD3 Protein(C-His Tag)

Recombinant Human TIMD3 Protein(C-His Tag)

PH0093M1
Catalog # Availability Size / Price Inquiry
PH0093M1-20μg 20μg / $325
PH0093M1-100μg 100μg / $955

Recombinant Human TIMD3 Protein(C-His Tag)

Brand

Leading Biology

Catalog Number

PH0093M1

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

Mammalian cell

Species

Human

AA Sequence

AAL65157.1(Met1-Arg200)

Tags

C-His

Molecular Weight

21KD

Activity

Measured by its binding ability in a functional ELISA.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene. HAVCR2 was first described in 2002 as a cell surface molecule expressed on IFNγ producing CD4+ Th1 and CD8+ Tc1 cells. Later, the expression was detected in Th17 cells, regulatory T-cells, and innate immune cells (dendritic cells, NK cells, monocytes).HAVCR2 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion. HAVCR2 has also been shown as a CD4+ Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

Synonyms

CD366 Protein(Human); HAVcr-2 Protein(Human); HAVCR2 Protein(Human); KIM-3 Protein(Human); Tim-3 Protein(Human); TIM3 Protein(Human); TIMD-3 Protein(Human)

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Quantity

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