> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Mouse DKK1 Protein(C-His Tag)Brand |
Leading Biology | Catalog Number |
PM0082M1 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
Mammalian cell
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Species |
Mouse
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AA Sequence |
NP_034181.2(Met1-His272)
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Tags |
C-His
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Molecular Weight |
27KD
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Activity |
Measured by its ability to inhibit Wnt induced TCF reporter activity in HEK293 human embryonic kidney cells.
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm. The dickkopf protein encoded by DKK1 is an antagonist of the Wnt/β-catenin signalling pathway that acts by isolating the LRP6 co-receptor so that it cannot aid in activating the WNT signaling pathway. DKK1 was also demonstrated to antagonize the Wnt/β-catenin pathway via a reduction in β-catenin and an increase in OCT4 expression. This inhibition plays a key role in heart, head and forelimb development during anterior morphogenesis of the embryo.
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Synonyms |
SK Protein(Mouse)
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Images |
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Quantity |
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