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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human CD40 Ligand Protein(C-His Tag)

Recombinant Human CD40 Ligand Protein(C-His Tag)

PH0065E1
Catalog # Availability Size / Price Inquiry
PH0065E1-20μg 20μg / $325
PH0065E1-100μg 100μg / $955

Recombinant Human CD40 Ligand Protein(C-His Tag)

Brand

Leading Biology

Catalog Number

PH0065E1

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

NP_000065.1(Glu 108-Leu 261)

Tags

C-His

Molecular Weight

18KD

Activity

Measured in a cell proliferation assay using B?cell-enriched peripheral blood mononuclear cells (PBMC) in the presence of IL-4

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4, 10% glycerol

Product Description

CD40 Ligand Protein receptor encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. The TNFR-receptor associated factor adaptor proteins TRAF1, TRAF2, TRAF6 and possibly TRAF5 interact with this receptor serve as mediators of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Synonyms

CD154 Protein(Human); CD40LG Protein(Human); CD40L Protein(Human); gp39 Protein(Human); hCD40L Protein(Human); HIGM1 Protein(Human); IGM Protein(Human); IMD3 Protein(Human); T-BAM Protein(Human); TNFSF5 Protein(Human); TRAP Protein(Human)

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Quantity

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