Introduction
Tissue microarray is a recent innovation in the field of pathology. A microarray contains many small representative tissue samples from hundreds of different cases assembled on a single histologic slide, and therefore allows high throughput analysis of multiple specimens at the same time.
In the tissue microarray technique, a hollow needle is used to remove tissue cores as small as 0.6 mm diameter from regions of interest in paraffin-embedded tissues such as clinical biopsies or tumor samples. These tissue cores are then inserted in a recipient paraffin block in a precisely spaced, array pattern. Sections from this block are cut using a microtome, mounted on a microscope slide and then analyzed by any method of standard histological analysis. Each microarray block can be cut into 100-500 sections, which can be subjected to independent tests. Tests commonly employed in tissue microarray include immunohistochemistry, and fluorescent in situ hybridization. Tissue microarrays are particularly useful in the analysis of cancer samples.
No | Headline | Click | Author | Date |
1 | Plant and Animal Whole Genome Re-Sequencing | 838 | Leading Biology | 2018-01-26 |
2 | Whole Exome Sequencing | 829 | Leading Biology | 2018-01-26 |
3 | Whole Transcriptome Shotgun Sequencing | 1142 | Leading Biology | 2018-01-26 |
4 | smallRNA/microRNA/circRNA/LncRNA Sequencing | 814 | Leading Biology | 2018-01-26 |
5 | Bacterial Genome Sequencing | 824 | Leading Biology | 2018-01-26 |
6 | Targeted Gene Sequencing | 925 | Leading Biology | 2018-01-26 |