> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human RSPO1 Protein(C-His Tag)Brand |
Leading Biology | Catalog Number |
PH0137M1 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
Mammalian cell
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Species |
Human
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AA Sequence |
NP_001033722.1(Met 1-Ala 263)
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Tags |
C-His
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Molecular Weight |
42KD
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Form |
lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene, found on chromosome 1. In humans, it interacts with WNT4 in the process of female sex development. Loss of function can cause female to male sex reversal. Furthermore, it promotes canonical WNT/β catenin signaling. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β-catenin, which activates downstream targets. If both are deficient in XY mice, there is less expression of SRY and a reduction in the amount of SOX9. Moreover, defects in vascularization are found. These occurrences result in testicular hypoplasia. Male to female sex reversal, however, does not occur because Leydig cells remain normal. They are maintained by steroidogenic cells, now unrepressed.
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Synonyms |
CRISTIN3 Protein(Human); R-Spondin 1 Protein(Human); RSPO Protein(Human)
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Images |
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Quantity |
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Leading Biology Inc.
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Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
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