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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human FGF21 Protein(N-His Tag)

Recombinant Human FGF21 Protein(N-His Tag)

PH0111E3
Catalog # Availability Size / Price Inquiry
PH0111E3-20μg  In Stock 20μg / $325
PH0111E3-100μg  In Stock 100μg / $955

Recombinant Human FGF21 Protein(N-His Tag)

Brand

Leading Biology

Catalog Number

PH0111E3

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

NP_061986.1(His 29-Ser 209)

Tags

N-His

Molecular Weight

23KD

Activity

Measured in a cell proliferation assay using BaF3 mouse pro?B cells transfected with human FGF RIIIc.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered 50 mM Tris, 10 % glycerol, 0.05 % Brij 35, pH 8.0

Product Description

FGF21 stimulates glucose uptake in adipocytes but not in other cell types. This effect is additive to the activity of insulin. FGF21 treatment of adipocytes is associated with phosphorylation of FRS2, a protein linking FGF receptors to the Ras/MAP kinase pathway. FGF21 injection in ob/ob mice results in an increase in Glut1 in adipose tissue. FGF21 also protects animals from diet-induced obesity when overexpressed in transgenic mice and lowers blood glucose and triglyceride levels when administered to diabetic rodents. Treatment of animals with FGF21 results in increased energy expenditure, fat utilization and lipid excretion. Beta Klotho (KLB) functions as a cofactor essential for FGF21 activity.

Synonyms

UNQ3115 / PRO10196 Protein(Human)

Quantity

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