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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Mouse FGF2 Protein(N-His Tag)

Recombinant Mouse FGF2 Protein(N-His Tag)

PM0105E3
Catalog # Availability Size / Price Inquiry
PM0105E3-20μg 20μg / $325
PM0105E3-100μg 100μg / $955

Recombinant Mouse FGF2 Protein(N-His Tag)

Brand

Leading Biology

Catalog Number

PM0105E3

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Mouse

AA Sequence

NP_032032.1(Ala11-Ser154)

Tags

N-His

Molecular Weight

18KD

Activity

Measured in a cell proliferation assay using NR6R-3T3 mouse fibroblast cells.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

FGF2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene. It is synthesized primarily as a 155 amino acid polypeptide, resulting in an 18 kDa protein. However, there are four alternate start codons which provide N-terminal extensions of 41, 46, 55, or 133 amino acids, resulting in proteins of 22 kDa (196 aa total), 22.5 kDa (201 aa total), 24 kDa (210 aa total) and 34 kDa (288 aa total), respectively. Generally, the 155 aa/18 kDa low molecular weight (LMW) form is considered cytoplasmic and can be secreted from the cell, whereas the high molecular weight (HMW) forms are directed to the cell's nucleus. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. Gene sequencing revealed that this group was in fact the same FGF2 protein and that it was a member of a family of FGF proteins. FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules.

Synonyms

bFGF Protein(Mouse); Fgf-2 Protein(Mouse); Fgfb Protein(Mouse)

Images

Quantity

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