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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human PD-1 Protein(C-His Tag)

Recombinant Human PD-1 Protein(C-His Tag)

PH0094M1
Catalog # Availability Size / Price Inquiry
PH0094M1-20μg  In Stock 20μg / $325
PH0094M1-100μg  In Stock 100μg / $955

Recombinant Human PD-1 Protein(C-His Tag)

Brand

Leading Biology

Catalog Number

PH0094M1

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

Mammalian cell

Species

Human

AA Sequence

NP_005009.2(Met 1-Gln 167)

Tags

C-His

Molecular Weight

17KD

Activity

Measured by its binding ability in a functional ELISA.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-1 inhibitors, a new class of drugs that block PD-1, activate the immune system to attack tumors and are used to treat certain types of cancer. The PD-1 protein in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells. PD-1 binds two ligands, PD-L1 and PD-L2.

Synonyms

CD279 Protein(Human); hPD-1 Protein(Human); hPD-l Protein(Human); hSLE1 Protein(Human); PD-1 Protein(Human); PD1 Protein(Human); SLEB2 Protein(Human)

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Specification

Quantity

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