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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human CXCL3 Protein(N-His Tag)

Recombinant Human CXCL3 Protein(N-His Tag)

PH0074E3
Catalog # Availability Size / Price Inquiry
PH0074E3-20μg 20μg / $325
PH0074E3-100μg 100μg / $955

Recombinant Human CXCL3 Protein(N-His Tag)

Brand

Leading Biology

Catalog Number

PH0074E3

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

NP_002081.2(Ala35-Asn107)

Tags

N-His

Molecular Weight

14KD

Activity

Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates its effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum. In fact, the reduced expression of Cxcl3 forces the cerebellar granule neuron precursors to remain at the surface of the cerebellum, where they highly proliferate under the stimulus of Sonic hedgehog, becoming target of transforming insults. Remarkably, the treatment with CXCL3 completely prevents the growth of medulloblastoma lesions in a Shh-type mouse model of medulloblastoma. Thus, CXCL3 is a target for medulloblastoma therapy. Cxcl3 is directly regulated transcriptionally by BTG2 The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.

Synonyms

CINC-2b Protein(Human); GRO gamma Protein(Human); GRO3 Protein(Human); GROG Protein(Human); MIP-2b Protein(Human); MIP2B Protein(Human); SCYB3 Protein(Human)

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Quantity

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