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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human CXCL1 Protein

Recombinant Human CXCL1 Protein

PH0072E2
Catalog # Availability Size / Price Inquiry
PH0072E2-20μg 20μg / $325
PH0072E2-100μg 100μg / $955

Recombinant Human CXCL1 Protein

Brand

Leading Biology

Catalog Number

PH0072E2

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

P09341-1(Ala35-Asn107)

Tags

Tag-Free

Molecular Weight

10KD

Activity

Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MGSA-α). In humans, this protein is encoded by the Cxcl1. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, arteriogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function.

Synonyms

CA21H Protein(Human); CAH1 Protein(Human); CPS1 Protein(Human); CYP21 Protein(Human); CYP21B Protein(Human); FSP Protein(Human); GRO1 Protein(Human); GROa Protein(Human); MGSA Protein(Human); MGSA-a Protein(Human); NAP-3 Protein(Human); P450c21B Protein(Human); SCYB1 Protein(Human)

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Quantity

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