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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human ANGPT2 Protein(N-His Tag)

Recombinant Human ANGPT2 Protein(N-His Tag)

PH0052M3
Catalog # Availability Size / Price Inquiry
PH0052M3-20μg 20μg / $325
PH0052M3-100μg 100μg / $955

Recombinant Human ANGPT2 Protein(N-His Tag)

Brand

Leading Biology

Catalog Number

PH0052M3

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

Mammalian cell

Species

Human

AA Sequence

NP_001138.1(Lys275-Phe496)

Tags

N-His

Molecular Weight

28KD

Activity

Measured by its ability to activate Tie-2 in C6 rat glial cells transfected with human Tie-2.

Form

lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.

Synonyms

ANG2 Protein(Human); Angiopoietin-2 Protein(Human); AGPT2 Protein(Human)

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