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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Mouse IL-7 Protein

Recombinant Mouse IL-7 Protein

PM0016E2
Catalog # Availability Size / Price Inquiry
PM0016E2-20μg  In Stock 20μg / $325
PM0016E2-100μg  In Stock 100μg / $955

Recombinant Mouse IL-7 Protein

Brand

Leading Biology

Catalog Number

PM0016E2

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Mouse

AA Sequence

NP_032397.1(Glu26-Ile154)

Tags

Tag-Free

Molecular Weight

18KD

Activity

Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL)

Form

Lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

The target cells of IL-7 are mainly lymphocytes, and have growth-promoting activities against B progenitor cells derived from human or mouse bone marrow, thymocytes, and peripheral mature T cells. Synergistic with stem cell growth factor (SCF) can stimulate mitosis of b precursor, which can be inhibited by tgf and inhibited; but has no significant effect on the growth of progenitor B (pro-b). Promote the maturation of double-negative thymocytes, and provide the initial signal of tcr gene recombination during embryonic thymocyte development; however, it has no obvious effect on mature T cells. Inducing thymocytes or peripheral blood lymphocytes to produce LAK cell activity, the effector cells are mainly CD8+ subpopulations; however, IL-7-induced LAK cells do not have NK activity.IL-7 can stimulate myeloid precursor cells and megakaryocytes to produce colony forming units and platelets, which can restore the body from the immunosuppressive effect of cyclophosphamide; at higher concentrations, IL-7 can also enhance macrophages. Cytotoxic activity, induces monocyte secretion of cytokines.

Synonyms

Interleukin-7 Protein (Mouse)

Images

Quantity

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