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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human IL-37 Protein

Recombinant Human IL-37 Protein

PH0045E2
Catalog # Availability Size / Price Inquiry
PH0045E2-20μg  In Stock 20μg / $325
PH0045E2-100μg  In Stock 100μg / $955

Recombinant Human IL-37 Protein

Brand

Leading Biology

Catalog Number

PH0045E2

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

Q9NZH6-2(Lys 27-Asp 192)

Tags

Tag-Free

Molecular Weight

18KD

Activity

Measured by its binding ability in a functional ELISA.

Form

Lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

Interleukin-37 (IL-37) is a natural inhibitor of immune and inflammatory responses and is involved as an anti-inflammatory factor in immune and inflammatory responses. IL-37 is a cytokine with both intracellular and extracellular functions. Its inhibitory inflammatory response and its involvement in immune regulation are mainly: IL-37 precursor is cleaved by cysteine-1 (Caspase-1). It becomes an active mature body, IL-37b, which enhances the inhibitory effect of 1L-18BP on IL-18 by binding to IL-18 binding protein (IL-18BP), thereby inhibiting interferon-Y (IF-N-γ) Generation; IL-37b transfer to cells to bind to smad3 to form IL-37b-Smad3 complex, thereby reducing the expression of some inflammatory signaling pathway-related kinases such as FAK, MAPK p38 and c-Jun.

Synonyms

FIL1 Protein (Human); FIL1Z Protein (Human); IL-1F7 Protein (Human); IL-1H Protein (Human); IL-1H4 Protein (Human); IL-1RP1 Protein (Human)

Images

Specification

Quantity

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