> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Mouse IL-36ɣ Protein (N-His Tag)Brand |
Leading Biology | Catalog Number |
PM0044E3 |
Product Type |
Cytokine | Field of Research |
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Nature |
Recombinant Protein
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Expression Host |
E.coli
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Species |
Mouse
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AA Sequence |
Q8R460(Gly13-Ser164)
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Tags |
N-His
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Molecular Weight |
20KD
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Activity |
Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells
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Form |
Lyophilized |
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Purity |
Greater than 95% by SDS-PAGE |
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Storage & Stability |
-70°C
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Storage Buffer |
0.2 μm filtered PBS, pH7.4
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Product Description |
Interleukin-36 (IL-36) was first discovered based on its homology to the IL-1 superfamily (IL-1F). IL-36 includes agonist IL. -36α, IL-36β, IL-36γ and inhibitor IL-36Ra, whose agonist mainly has pro-inflammatory function. IL-36Ra acts as a natural inhibitor of IL-36 agonist binding to IL-36R and inhibiting agonist ligands. Binding. IL-36 is biologically active in epithelial cells and specific immune cells. Its functions include cell activation, secretion of cytokines and chemokines, recruitment and activation of different immune cells, etc. Especially in psoriasis. In pathology, IL-36 has a wide range of effects. Recent research data also demonstrate the role of the IL-36 family in the physiology and pathology of the lung.
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Synonyms |
IL-1F9 Protein (Mouse); IL-1H1 Protein (Mouse); IL-1RP2 Protein (Mouse);IL-36G Protein (Mouse)
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Images |
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Quantity |
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