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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human IL-35 Protein

Recombinant Human IL-35 Protein

PH0042M2
Catalog # Availability Size / Price Inquiry
PH0042M2-20μg  In Stock 20μg / $325
PH0042M2-100μg  In Stock 100μg / $955

Recombinant Human IL-35 Protein

Brand

Leading Biology

Catalog Number

PH0042M2

Product Type

Cytokine

Field of Research

Nature

Recombinant Protein

Expression Host

Mammalian cell

Species

Human

AA Sequence

NP_000873.2(Met1-Ser219)&NP_005746.2(Met1-Lys229)

Tags

Tag-Free

Molecular Weight

60 & 63 KD

Activity

Measured by its ability to induce IL-8 secretion in A431 human epithelial carcinoma cells

Form

Lyophilized

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70°C

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

Interleukin-35 (IL-35) is a new member of the IL-12 family discovered in recent years. It is a heterodimer composed of α-chain p35 and β-chain Epstein-Barr virus-inducible gene 3 (EBI3), and receptors. IL12Rβ2 and glycoprotein 130 (gp130) bind to JAK-STAT signaling pathway and participate in a variety of inflammatory and autoimmune diseases by regulating the differentiation and function of T cells, B cells, dendritic cells and macrophages. The occurrence and development. Recent studies have found that in rheumatoid immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, polymyositis, dermatomyositis, Behcet's syndrome, Sjogren's syndrome, etc., IL-35 expression is abnormal and significant activity with disease Related.

Synonyms

IL12A&IL27B

Images

Specification

Quantity

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