> Proteins, Peptides & Amino Acids > Recombinant Protein > Cytokine > Recombinant Human IL-24 Protein (C-His Tag)Brand |
Leading Biology | Catalog Number |
PH0033M1 |
Product Type |
Cytokine | Field of Research |
|
Nature |
Recombinant Protein
|
||
Expression Host |
Mammalian cell
|
||
Species |
Human
|
||
AA Sequence |
NP_001172085.1(Met 1-Leu 207)
|
||
Tags |
C-His
|
||
Molecular Weight |
35KD
|
||
Activity |
Measured in a cell proliferation assay using BaF3 mouse pro?B cells transfected with human IL-20 R alpha and human IL-20 R beta.
|
||
Form |
Lyophilized |
||
Purity |
Greater than 95% by SDS-PAGE |
||
Storage & Stability |
-70°C
|
||
Storage Buffer |
0.2 μm filtered PBS, pH7.4
|
||
Product Description |
IL24 is a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. IL-10B encoded can induce apoptosis selectively in various cancer cells. Overexpression IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. The glycosylation is essential for activity of IL-24. Functionally, IL-24 has diverse activities. At low concentrations, it induces type I proinflammatory cytokines such as IFN-?, IL-1?, IL-12 and TNF-?. At high concentration, it is a strong inducer of apoptosis in tumor cells, but not normal cells. mda-7/IL-24 is being hailed as a ‘magic bullet’ for cancer gene therapy.
|
||
Synonyms |
C49A Protein (Human); FISP Protein (Human)
|
||
Images |
|
||
Quantity |
|
||
| Select | Brand | Catalog No. | Product Name | Pack Size | Type | Field of Research | Specification | Quantity | Price(USD) | |
| 1 | Leading Biology | PH0003E1 | Recombinant Human TNF Alpha Protein | 10ug | Cytokine |
|
$195.00 | Add Ask | ||
| 2 | Leading Biology | PH0001E2 | Recombinant Human IL-6 Protein | 10ug | Cytokine |
|
$195.00 | Add Ask | ||
| 3 | Leading Biology | PH0073E2 | Recombinant Human CXCL2 Protein | 20μg | Cytokine |
|
$325.00 | Add Ask | ||
| 4 | Leading Biology | PH0024E3 | Recombinant Human IL-16 Protein (N-His Tag) | 20μg | Cytokine |
|
$325.00 | Add Ask | ||
| 5 | Leading Biology | PH0045E2 | Recombinant Human IL-37 Protein | 20μg | Cytokine |
|
$325.00 | Add Ask | ||
| 6 | Leading Biology | PH0041M1 | Recombinant Human IL-34 Protein (C-His Tag) | 20μg | Cytokine |
|
$325.00 | Add Ask |
Leading Biology Inc.
2600 Hilltop DR, Building G, B Suite C138
Richmond, CA, 94806
Tel: 1-661-524(LBI)-0262
Email: info@leadingbiology.com
You have 0 item in your cart
You have 0 item in your inquiry list
