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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Recombinant Human FGL1 Protein

Recombinant Human FGL1 Protein

PH0005E1
Catalog # Availability Size / Price Inquiry
PH0005E1-10ug  In Stock 10μg / $195
PH0005E1-50ug  In Stock 50μg / $695
PH0005E1-200ug  In Stock 200μg / $1245

Recombinant Human FGL1 Protein

Brand

Leading Biology

Catalog Number

PH0005E1

Product Type

Recombinant Protein

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

NP_004458.3 (Leu 23-Ile 312)

Molecular Weight

35 KD

Activity

Measured by its ability to bind biotinylated LAG3 domain1/2 in functional ELISA.

Form

Liquid

Concentration

0.6mg/mL

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70ºC

Storage Buffer

0.2 μm filtered PBS, pH7.4

Product Description

Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner.

Synonyms

Fibrinogen-like protein 1 (human), HFREP1 Protein, Human; HP-041 Protein, Human; LFIRE-1 Protein, Human; LFIRE1 Protein, Human

Images

Specification

Quantity

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