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Location: Home > Proteins, Peptides & Amino Acids > Recombinant Protein > Recombinant Human STING Protein

Recombinant Human STING Protein

PH0009E2
Catalog # Availability Size / Price Inquiry
PH0009E2-10μg  In Stock 10μg / $195
PH0009E2-50μg  In Stock 50μg / $695
PH0009E2-200μg  In Stock 200μg / $1245

Recombinant Human STING Protein

Brand

Leading Biology

Catalog Number

PH0009E2

Product Type

Recombinant Protein

Field of Research

Nature

Recombinant Protein

Expression Host

E.coli

Species

Human

AA Sequence

NP_938023.1 (Lys 137-Ser 379)

Molecular Weight

27.4 KD

Activity

The result from the ITC assay showed that cGAMP bound Recombinant Human STING Protein with a dissociation constant of 0.02 μM.

Form

Liquid

Concentration

10μg-0.3mg/mL 50μg-0.75mg/mL 200μg-1mg/mL

Purity

Greater than 95% by SDS-PAGE

Storage & Stability

-70ºC

Storage Buffer

0.2 μm filtered 50mM Tris-HCl, 150mM NaCl, pH7.5

Product Description

Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP.(Microbial infection) Antiviral activity is antagonized by oncoproteins, such as papillomavirus (HPV) protein E7 and adenovirus early E1A protein (PubMed: 26405230). Such oncoproteins prevent the ability to sense cytosolic DNA.

Synonyms

ERIS protein, Human; MITA protein ,Human; Transmembrane protein 173

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