Introduction of Liposome

Liposome is a new type of pharmaceutical preparation with targeted drug delivery function. In general, a liposome is a spherical vesicle which contains at least one lipid bilayer. A similar structure with the body’s plasma membrane results in the great biocompatibility of liposomes. In recent years, liposomes have been widely used as carriers of different kinds of antigens. The attached position of antigens to liposomes can be the outer surface, the internal aqueous spaces, and the lipid bilayers. The theoretical basis of liposome immunization is that liposomes have the ability to encapsulate antigens and stimulate antibody production at low doses. Moreover, the potential allergic reactions can also be avoided.

Liposome-based Immunization Strategy

A liposome is a new type of immunogen delivery system which is used to induce immune responses in intranasal, intramuscular, or intraperitoneal immunization. It has been recognized as a novel adjuvant and vaccine delivery system thanks to its unique advantages over traditional carrier proteins on immunogenic stimulation. For example, the sizes, charges, and components of liposomes could be easily adjusted to cope with the need of different antigens; liposomes increase the antigen presentation to APCs and convert the non-immunogenic substance to an immunogenic one; there are no side-effects during the vaccine research and development. Our liposome immunization service combines liposome encapsulation, specific delivery sites and the use of a heterologous immunization regimen. The size of liposomes produced in Creative Biolabs is designed to be around 200 nm as liposomes with diameters less than 500 nm was shown to efficiently enhance immunogenic performance.

The liposome carrier was considered as a new adjuvant and vaccine delivery vector due to its excellent antigen stimulating activity. Because the size, membrane potential and membrane components of the liposome can be freely adjusted, the liposome vectors have advantages which traditional carrier proteins do not have, they can transform some low immunogenicity even non-immunogenic antigens into Immunogens, increase their opportunities to contact with the antigen presenting cell (APC) and processing to effective antigens, and most importantly, the liposomes are very helpful for the research and development of some vaccines since the carrier itself does not have the side effect.

Based on the experience of liposome research, Leading Biology developed a complete set of preparation method of antibody against low immunogenicity antigen based on liposome as an emulsifying carrier. The volume of the liposomes after packing is strictly controlled at about 200nm, which is a valuable and practical experience accumulated by our technicians in the long time project operation.

Why Leading Biology?

As one of the most important stages of our antibodies production service, liposome immunization plays an important role. Based on the specific antigens and immunized animals, we are able to choose the best-attached method for the purpose of high-efficient antibody production.

Leading Biology is the leading liposome immunization company that serves the global market. With our unparalleled expertise in this field, we have achieved high titers of effective antibodies production with many antigen encapsulated liposomes for our clients all over the world. If you are interested in our liposome immunization service, please do not hesitate to inquire for more details.

Related Services

Anti-Membrane Protein Antibody Discovery

Anti-autologous Antigen Antibody Production Service

Antibody Production by Liposome Immunization

Anti-hapten Antibody Production Service

Membrane Protein Antibody Production

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